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These treatments may be: antiviral ointments, such as docosanol anesthetic ointments, such as benzocaine (Orajel), lidocaine, or tetracaine (Pontocaine) It may also help to: apply a cool compress or ice pack to the sore or the general area when tingling sensations first occur use over-the-counter pain relief medication, such as ibuprofen or acetaminophen, to ease discomfort avoid foods that could cause a burning sensation, such as acidic fruits and spicy or salty food If people have more severe cold sore outbreaks, they may need a prescription-strength medication, such as acyclovir (Zovirax) or penciclovir (Denavir)